Entecavir
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IMPORTANT WARNING:
| Entecavir can cause serious or life-threatening damage to the liver and a condition called lactic acidosis (a build-up of acid in the blood).Tell your doctor if you drink or have ever drunk large amounts of alcohol, if you use or have ever used injectable street drugs, and if you have or have ever had cirrhosis (scarring) of the liver or any liver disease other than hepatitis B. Tell your doctor and pharmacist if you are taking or have taken the following medications: acetaminophen (Tylenol, others);cholesterol-lowering medications (statins);iron products;isoniazid (INH, Nydrazid); medications to treat human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS);methotrexate (Rheumatrex);niacin (nicotinic acid);or rifampin (Rifadin, Rimactane). If you experience any of the following symptoms, call your doctor immediately: yellowing of the skin or eyes; dark-colored urine; light-colored bowel movements; difficulty breathing; stomach pain or swelling; upset stomach; vomiting;unusual muscle pain;loss of appetite for at least several days; lack of energy; extreme weakness or tiredness;feeling cold especially in the arms or legs; dizziness or lightheadedness; or fast or irregular heartbeat.Do not stop taking entecavir without talking to your doctor. When you stop taking entecavir your hepatitis may get worse. This is most likely to happen during the first several months after you stop taking entecavir. Be careful not to miss doses or run out of entecavir. Refill your prescription at least 5 days before you expect that you will need the new supply of medication. If you experience any of the following symptoms after you stop taking entecavir, call your doctor immediately: extreme tiredness, weakness, upset stomach, vomiting, loss of appetite yellowing of the skin or eyes, dark-colored urine, light-colored bowel movements, and muscle or joint pain.Keep all appointments with your doctor and the laboratory before, during, and for a few months after your treatment with entecavir. Your doctor will order certain tests to check your body’s response to entecavir during this time. Talk to your doctor about the risks of taking entecavir. |
Why is this medication prescribed?
Entecavir is used to treat chronic (long-term) hepatitis B infection (swelling of the liver caused by a virus) in people who show signs of liver damage. Entecavir is in a class of medications called nuceloside analogs. It works by decreasing the amount of hepatitis B virus (HBV) in the body. Entecavir does not cure hepatitis B and may not prevent complications of chronic hepatitis B such as cirrhosis of the liver or liver cancer. Entecavir does not prevent the spread of hepatitis B to other people.
How should this medicine be used?
Entecavir comes as a tablet and solution (liquid) to take by mouth. It is usually taken once a day on an empty stomach, at least 2 hours after a meal and at least 2 hours before the next meal. Take entecavir at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take entecavir exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
To use the entecavir solution, follow these steps:
- Hold the spoon that came with your medication upright and slowly fill it with entecavir solution up to the mark that matches your dose.
- Hold the spoon with the volume marks facing you and check to see that the top of the liquid is level with the mark that matches your dose.
- Swallow the medication right from the measuring spoon. Do not mix the medication with water or any other liquid
- Rinse the spoon with water after each use, and allow it to air dry.
- Put the spoon in a safe place where it will not get lost, because you will need to use it every time you take your medication. If you do lose the dosing spoon, call your doctor or pharmacist.
Your doctor or pharmacist will give you the manufacturer’s patient information sheet to read before you start taking entecavir and every time you refill the prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions.
Other uses for this medicine
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
What special precautions should I follow?
Before taking entecavir,
- tell your doctor and pharmacist if you are allergic to entecavir, or any of its ingredients, or any other medications. Ask your pharmacist for a list of ingredients in entecavir.
- tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention the medications listed in the IMPORTANT WARNING section and any of the following: aminoglycoside antibiotics such as amikacin (Amikin), gentamicin (Garamycin), kanamycin (Kantrex), neomycin (Neo-Rx, NeoFradin), paramomycin (Humatin), streptomycin, and tobramycin (Tobi, Nebcin); amphotericin B (Fungizone); aspirin and other nonsteroidal anti-inflammatory medications (NSAIDs) such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn); medications to prevent rejection of a transplanted organ such as cyclosporine (Neoral, Sandimmune) or tacrolimus (Prograf); probenecid; or vancomycin Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
- tell your doctor if you have had a liver transplant (surgery to replace a diseased liver), or if you have or have ever had kidney disease.
- tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking entecavir, call your doctor. Do not breastfeed while you are taking entecavir.
- if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking entecavir.
What special dietary instructions should I follow?
Unless your doctor tells you otherwise, continue your normal diet.
What should I do if I forget a dose?
Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
What side effects can this medication cause?
Entecavir may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- headache
- dizziness
- diarrhea
- heartburn
- drowsiness
- difficulty falling asleep or staying asleep
Some side effects can be serious. If you experience any of the symptoms listed in the IMPORTANT WARNING section, call your doctor immediately.
Entecavir may cause other side effects. Call your doctor if you have any unusual problems while using this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/MedWatch/report.htm] or by phone [1-800-332-1088].
What storage conditions are needed for this medicine?
Keep this medication in the container it came in, tightly closed, and out of reach of children and pets. Store it at room temperature and away from excess heat, light, and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed by flushing the tablets down the toilet or pouring the solution down the sink. Talk to your pharmacist about the proper disposal of your medication.
In case of emergency/overdose
In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.
What other information should I know?
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
Brand names
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Last Revised - 07/01/2005